製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-NSAQRRLGDSSDL
    • 領域158 to 170

特性

Our Abpromise guarantee covers the use of ab23004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • GRP4_HUMAN
    • Guanyl nucleotide releasing protein 4
    • RAS guanyl releasing protein 4
    • RAS guanyl-releasing protein 4
    • RASGRP4
    see all
  • 機能Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • 組織特異性Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
  • 配列類似性Belongs to the RASGRP family.
    Contains 1 EF-hand domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-GEF domain.
  • 発生段階Expressed early during development. Detected in all fetal tissues tested.
  • ドメインThe phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • 細胞内局在Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
  • Information by UniProt

Human RASGRP 4 peptide (ab23004) 使用論文

ab23004 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"