製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列ASEDIAKLAETLAK-C
    • 領域2 to 15

関連製品

特性

Our Abpromise guarantee covers the use of ab22867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-RanGAP1 antibody (ab2081)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Fug 1
    • Fug1
    • GTPase-activating protein, RAN, 1
    • KIAA1835
    • MGC20266
    • OTTHUMP00000028918
    • OTTHUMP00000198755
    • OTTHUMP00000198756
    • OTTHUMP00000198757
    • OTTHUMP00000198758
    • RAGP1_HUMAN
    • Ran 1
    • RAN GTPase activating protein 1
    • Ran GTPase-activating protein 1
    • Ran1
    • RANGAP
    • RANGAP 1
    • RanGAP1
    • SD
    • Segregation distorter homolog
    • Segregation distortion
    see all
  • 機能GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
  • 組織特異性Highly expressed in brain, thymus and testis.
  • 配列類似性Belongs to the RNA1 family.
    Contains 6 LRR (leucine-rich) repeats.
  • 翻訳後修飾Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
    Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
  • 細胞内局在Cytoplasm. Nucleus membrane. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
  • Information by UniProt

Human RanGAP1 peptide (ab22867) 使用論文

ab22867 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"