製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      TRSAW
    • 領域
      107 to 111

特性

Our Abpromise guarantee covers the use of ab42283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

関連情報

  • 別名
    • HHM
    • MGC14611
    • Osteostatin
    • Parathyroid hormon like hormone isoform 2 preproprotein
    • Parathyroid hormone like hormone
    • Parathyroid hormone like hormone isoform 1 preproprotein
    • Parathyroid hormone like protein
    • Parathyroid hormone like related protein
    • Parathyroid hormone related protein
    • Parathyroid hormone-like protein
    • Parathyroid like protein
    • PLP
    • PTH related protein
    • PTH-rP
    • PTHLH
    • PTHR
    • PTHR_HUMAN
    • PTHrP
    • PTHrP[107-139]
    see all
  • 機能
    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • 組織特異性
    Ubiquitous. Also expressed in the mammary gland.
  • 関連疾患
    Brachydactyly E2
  • 配列類似性
    Belongs to the parathyroid hormone family.
  • 翻訳後修飾
    There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
  • 細胞内局在
    Cytoplasm. Nucleus. Secreted.
  • Information by UniProt

Human PTHLH peptide (ab42283) 使用論文

ab42283 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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