Human PTHLH peptide (ab42283)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Blocking
製品の詳細
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製品名
Human PTHLH peptide
PTHLH タンパク質・ペプチド 製品一覧 -
精製度
> 95 % HPLC. -
Animal free
No -
由来
Synthetic -
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生物種
Human -
配列
TRSAW -
領域
107 to 111
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特性
Our Abpromise guarantee covers the use of ab42283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Blocking
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 0.1% Acetic acid
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再構成Store at 2 to -8°C lyophilised, resuspend in 0.1% actetic acid
関連情報
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別名
- HHM
- MGC14611
- Osteostatin
see all -
機能
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
組織特異性
Ubiquitous. Also expressed in the mammary gland. -
関連疾患
Brachydactyly E2 -
配列類似性
Belongs to the parathyroid hormone family. -
翻訳後修飾
There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
細胞内局在
Cytoplasm. Nucleus. Secreted. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab42283 は論文での使用が確認できていません。