製品の概要

製品の詳細

  • 由来
    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab30553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 製品の状態
    Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • 72 kDa ICln binding protein
    • 72 kDa ICln-binding protein
    • ANM5_HUMAN
    • Histone synthetic lethal 7, S. cerevisiae, homolog of
    • Histone-arginine N-methyltransferase PRMT5
    • HMT1 hnRNP methyltransferase like 5
    • HOMOLOG OF; SKB1
    • HRMT1L5
    • IBP72
    • Jak-binding protein 1
    • JBP 1
    • JBP1
    • PRMT 5
    • PRMT5
    • Protein arginine methyltransferase 5
    • Protein arginine N methyltransferase 5
    • Protein arginine N methyltransferase 5 N terminally processed
    • Protein arginine N-methyltransferase 5
    • S. POMBE
    • S. POMBE HOMOLOG OF; SKB1
    • SHK1 KINASE BINDING PROTEIN 1
    • Shk1 kinase binding protein 1 homolog
    • Shk1 kinase-binding protein 1 homolog
    • Shk1 kinase/binding protein 1, S. pombe, homolog of
    • SKB 1
    • SKB1
    • SKB1 homolog
    • SKB1: SKB1 homolog (S. pombe)
    • SKB1Hs
    see all
  • 機能
    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
  • 組織特異性
    Ubiquitous.
  • 配列類似性
    Belongs to the protein arginine N-methyltransferase family.
  • 翻訳後修飾
    Disulfide bonds and non-covalent association mediate homooligomers formation.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt

参考文献

ab30553 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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