製品の概要

  • 製品名Human PP2A alpha + beta peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-EPHVTRRTPDYFL
    • 領域297 to 309

関連製品

特性

Our Abpromise guarantee covers the use of ab22802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-PP2A alpha + beta antibody (ab1309)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • PP2A A
    • PP2A alpha
    • PP2A B
    • PP2A beta
    • PP2A-alpha
    • PP2AA_HUMAN
    • PP2Ac
    • PP2CB
    • PPP2CA
    • PPP2CB
    • Protein phosphatase 2 catalytic subunit alpha isoform
    • Protein phosphatase 2 catalytic subunit beta isoform
    • Replication protein C
    • RP C
    • RP-C
    • Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform
    • Serine/threonine protein phosphatase 2A catalytic subunit beta isoform
    • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    see all
  • 機能PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
  • 配列類似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 翻訳後修飾Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle.
    Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • 細胞内局在Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2.
  • Information by UniProt

Human PP2A alpha + beta peptide (ab22802) 使用論文

ab22802 has not yet been referenced specifically in any publications.

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