製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      SMLAERRRKQKWAV-C
    • 領域
      2 to 15

関連製品

特性

Our Abpromise guarantee covers the use of ab22903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-PINX1 antibody (ab2344)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • 67-11-3 protein
    • FLJ20565
    • Hepatocellular carcinoma-related putative tumor suppressor
    • Liver-related putative tumor suppressor
    • LPTL
    • LPTS
    • MGC8850
    • OTTHUMP00000224984
    • OTTHUMP00000224985
    • OTTHUMP00000224986
    • OTTHUMP00000225053
    • OTTHUMP00000225054
    • PIN2 interacting protein 1
    • Pin2-interacting protein X1
    • PIN2/TERF1-interacting telomerase inhibitor 1
    • PINX1
    • PINX1_HUMAN
    • Protein 67-11-3
    • TRF1-interacting protein 1
    see all
  • 機能
    Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • 組織特異性
    Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • 配列類似性
    Belongs to the PINX1 family.
    Contains 1 G-patch domain.
  • ドメイン
    The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • 細胞内局在
    Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt

Human PINX1 peptide (ab22903) 使用論文

ab22903 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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