製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列LVRALLQREA SKRPSARVAA N
    • 領域484 to 504

関連製品

特性

Our Abpromise guarantee covers the use of ab30903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-PINK1 antibody (ab23707)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, 200ul Tris buffered saline. pH 7.4

関連情報

  • 別名
    • BRPK
    • FLJ27236
    • mitochondrial
    • PARK 6
    • PARK6
    • Phosphatase and Tensin Homolog
    • PINK 1
    • PINK1
    • PINK1_HUMAN
    • Protein kinase BRPK
    • PTEN induced putative kinase 1
    • PTEN induced putative kinase protein 1
    • PTEN-induced putative kinase protein 1
    • Serine/threonine kinase PINK1 mitochondrial
    • Serine/threonine protein kinase PINK1 mitochondrial
    • Serine/threonine-protein kinase PINK1
    see all
  • 機能Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
  • 組織特異性Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
  • 関連疾患Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
  • 配列類似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated.
  • 細胞内局在Mitochondrion outer membrane. Cytoplasm > cytosol.
  • Information by UniProt

Human PINK1 peptide (ab30903) 使用論文

ab30903 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"