The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Epididymis luminal protein 117
Epididymis secretory protein Li 53
HEL S 53
Neuron cytoplasmic protein 9.5
Protein gene product 9.5
Ubiquitin C terminal esterase L1
Ubiquitin C terminal hydrolase
Ubiquitin C terminal hydrolase L1
Ubiquitin carboxyl terminal esterase L1
Ubiquitin carboxyl terminal hydrolase isozyme L1
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ubiquitin thioesterase L1
Ubiquitin thiolesterase L1
機能Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
組織特異性Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
関連疾患Parkinson disease 5 Neurodegeneration with optic atrophy, childhood-onset
配列類似性Belongs to the peptidase C12 family.
細胞内局在Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.