Anti-Human Papillomavirus 16 (E7) 抗体 [SPM405] (ab19938)

製品の概要

  • 製品名Anti-Human Papillomavirus 16 (E7) antibody [SPM405]
    Human Papillomavirus 16 (E7) 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM405] to Human Papillomavirus 16 (E7)
  • アプリケーション適用あり: Flow Cyt, ICC/IFmore details
  • 種交差性
    交差種: Human Papillomavirus (HPV)
  • 免疫原

    Recombinant full length protein (HPV type 16).

  • ポジティブ・コントロール
    • Cervical tissue infected with HPV16.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 10% PBS, BSA, pH 7.4
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名SPM405
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab19938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 関連性E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • 細胞内局在Nuclear
  • 参照データベース
    • 別名
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    Anti-Human Papillomavirus 16 (E7) antibody [SPM405] (ab19938) 使用論文

    ab19938 has not yet been referenced specifically in any publications.

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    The conc of this product is 200 ug/ml. The product can be further diluted 1/50 or 1/100 for sue in ICC/IF and Flow Cytometry. Please note the dilutions has to be optimized by the end user. Try lowest dilution fir...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"