Anti-Human Papillomavirus 16 (E7) 抗体 [716-281] (ab82601)

製品の概要

  • 製品名Anti-Human Papillomavirus 16 (E7) antibody [716-281]
    Human Papillomavirus 16 (E7) 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [716-281] to Human Papillomavirus 16 (E7)
  • 特異性ab82601 recognizes HPV oncoprotein E7, types 16 and 18 (both monomer and dimer forms by Western blot).
  • アプリケーション適用あり: WB, Sandwich ELISAmore details
  • 種交差性
    交差種: Human Papillomavirus (HPV)
  • 免疫原

    HPV oncoprotein E7, type 16.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)Chromatography on protein G Sepharose.
  • ポリ/モノモノクローナル
  • クローン名716-281
  • ミエローマSp2/0
  • アイソタイプIgG2b
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab82601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution.

ターゲット情報

  • 関連性E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • 細胞内局在Nuclear
  • 参照データベース
    • 別名
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    Anti-Human Papillomavirus 16 (E7) antibody [716-281] (ab82601) 使用論文

    ab82601 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"