製品の概要

  • 製品名Human NUMBL peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列SRSAAASGGPRRPE-C
    • 領域2 to 15

関連製品

特性

Our Abpromise guarantee covers the use of ab23104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-NUMBL antibody (ab5641)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • CAG 3A
    • CAG3A
    • CTG 3a
    • CTG3a
    • NBL
    • NUMB Drosophilia Homolog Like
    • Numb homolog (Drosophila) like
    • Numb homolog like
    • Numb like protein
    • NUMB R
    • Numb-like protein
    • Numb-R
    • Numb-related gene
    • Numb-related protein
    • NUMBL
    • NUMBL_HUMAN
    • NUMBLIKE
    • NUMBR
    • TNRC 23
    • TNRC23
    • Trinucleotide repeat-containing gene 23
    see all
  • 機能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 配列類似性Contains 1 PID domain.
  • ドメインThe PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 細胞内局在Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt

Human NUMBL peptide (ab23104) 使用論文

ab23104 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"