製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human

関連製品

特性

Our Abpromise guarantee covers the use of ab39823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    Blocking - Blocking peptide for Anti-Noxa antibody (ab36833)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • Adult T cell leukemia derived PMA responsive
    • APR
    • APR_HUMAN
    • ATL-derived
    • Immediate early response protein APR
    • Immediate-early-response protein APR
    • NOXA
    • Phorbol 12 myristate 13 acetate induced protein 1
    • Phorbol-12-myristate-13-acetate-induced protein 1
    • PMA induced protein 1
    • PMA-induced protein 1
    • PMA-responsive gene
    • Pmaip1
    • Protein Noxa
    see all
  • 機能
    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • 組織特異性
    Highly expressed in adult T-cell leukemia cell line.
  • 配列類似性
    Belongs to the PMAIP1 family.
  • ドメイン
    The BH3 motif is essential for pro-apoptotic activity.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt

参考文献

ab39823 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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