製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      IASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

関連製品

特性

Our Abpromise guarantee covers the use of ab111671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-NOX2/gp91phox antibody (ab80508)

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • 再構成
    Add 100ul of distilled water. Final peptide concentration is 1 mg/ml in water.

関連情報

  • 別名
    • AMCBX2
    • CGD
    • CGD91-phox
    • CY24B_HUMAN
    • CYBB
    • Cytochrome b 245, beta polypeptide
    • Cytochrome b(558) beta chain
    • Cytochrome b(558) subunit beta
    • Cytochrome b-245 heavy chain
    • Cytochrome b558 subunit beta
    • GP91 PHOX
    • gp91-1
    • gp91-phox
    • GP91PHOX
    • Heme-binding membrane glycoprotein gp91phox
    • NADPH oxidase 2
    • Neutrophil cytochrome b 91 kDa polypeptide
    • NOX2
    • p22 phagocyte B-cytochrome
    • P91 PHOX
    • p91-PHOX
    • Superoxide-generating NADPH oxidase heavy chain subunit
    see all
  • 機能
    Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
  • 関連疾患
    Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
  • 配列類似性
    Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • 翻訳後修飾
    Glycosylated.
  • 細胞内局在
    Membrane.
  • Information by UniProt

参考文献

ab111671 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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