製品の概要

  • 製品名Human nmt55 / p54nrb peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-NRAAPGAEFAPNK
    • 領域455 to 467

関連製品

特性

Our Abpromise guarantee covers the use of ab50439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-nmt55 / p54nrb antibody (ab50411)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • 52 kDa subunit
    • 54 kDa nuclear RNA and DNA binding protein
    • 54 kDa nuclear RNA- and DNA-binding protein
    • 55 kDa nuclear protein
    • DNA binding p52/p100 complex 52 kDa subunit
    • DNA-binding p52/p100 complex
    • NMT 55
    • NMT55
    • Non Pou domain containing octamer (ATGCAAAT) binding protein
    • Non POU domain containing octamer binding
    • Non POU domain containing octamer binding protein
    • Non-POU domain-containing octamer-binding protein
    • Nono
    • NonO protein
    • NONO_HUMAN
    • NRB
    • NRB 54
    • NRB54
    • Nuclear RNA binding protein 54kD
    • P54
    • p54(nrb)
    • p54nrb
    • PPP1R114
    • Protein phosphatase 1 regulatory subunit 114
    see all
  • 機能DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as an heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. Nono is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
  • 組織特異性Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
  • 関連疾患Note=A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.
  • 配列類似性Contains 2 RRM (RNA recognition motif) domains.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human nmt55 / p54nrb peptide (ab50439) 使用論文

ab50439 has not yet been referenced specifically in any publications.

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