製品の概要

  • 製品名Human Munc 13 peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-KLKSESRSTEEGS
    • 領域1579 to 1591

特性

Our Abpromise guarantee covers the use of ab45487 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • KIAA1032
    • Munc13-1
    • Protein unc-13 homolog A
    • UN13A
    • UN13A_HUMAN
    • Unc 13 homolog A
    • Unc13a
    • Unc13a (gene name)
    • Unc13h1 (gene name)
    see all
  • 関連性Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Tissue specificity: Expressed in pancreatic islet cells (PubMed:12871971). Expressed in melanocytes (PubMed:23999003). Similarity: Belongs to the unc-13 family. Contains 3 C2 domains. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 MHD2 (MUNC13 homology domain 2) domain. Contains 1 phorbol-ester/DAG-type zinc finger. Domain: The C2 domains are not involved in calcium-dependent phospholipid binding. The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity.
  • 細胞内局在Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction; synapse, presynaptic cell membrane. Note: Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding

Human Munc 13 peptide (ab45487) 使用論文

ab45487 has not yet been referenced specifically in any publications.

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