製品の概要

  • 製品名Human MSH3 peptide

製品の詳細

  • 由来Synthetic

特性

Our Abpromise guarantee covers the use of ab74606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度70 - 90% by HPLC.

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • Divergent upstream protein
    • DNA mismatch repair protein
    • DNA mismatch repair protein Msh 3
    • DNA mismatch repair protein MSH3
    • DUC 1
    • DUC1
    • DUG
    • DUP
    • hMSH3
    • MGC163306
    • MGC163308
    • Mismatch repair protein 1
    • MRP 1
    • MRP1
    • MSH 3
    • MSH3
    • MSH3_HUMAN
    • MutS homolog 3
    • MutS homolog 3 (E. coli)
    see all
  • 機能Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
  • 関連疾患Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
  • 配列類似性Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt

Human MSH3 peptide (ab74606) 使用論文

ab74606 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"