製品の概要

  • 製品名Human MDFIC peptide

製品の詳細

  • 由来Synthetic

特性

Our Abpromise guarantee covers the use of ab86656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度70 - 90% by HPLC.

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • HIC
    • Human I mfa domain containing protein
    • Human I-mfa domain-Containing protein
    • I mfa domain containing protein
    • MyoD family inhibitor domain containing protein
    • MyoD family inhibitor domain-containing protein
    • p32
    • p40
    see all
  • 関連性MDFIC is a cellular factor capable of modulating the expression of cellular and viral promoters. Its synthesis is controlled at the translational level by two different codons, an ATG and an upstream non-ATG translational initiator, allowing the production of two protein isoforms that present different subcellular localizations, p32 (isoform 2) being mainly distributed throughout the cytoplasm, whereas p40 (isoform 1) is targeted to the nucleolus. MDFIC is known to down-regulate Tat-dependent transcription of HIV-1 LTR by interacting with HIV-1 Tat and Rev proteins and impairing their nuclear import (possibly by rendering the NLS domains inaccessible to importin-beta) and stimulate activation of human T-cell leukaemia virus type I (HTLV-I) LTR. In human cells, MDFIC binds to the axin complex, resulting in an increase in the level of free beta-catenin; it affects axin regulation of the WNT and JNK signalling pathways.
  • 細胞内局在Cytoplasmic and Nuclear

Human MDFIC peptide (ab86656) 使用論文

ab86656 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"