製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      AMDSSLQARLFPG-C
    • 領域
      2 to 14

特性

Our Abpromise guarantee covers the use of ab23137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • 4930402F02Rik
    • CT139
    • ESTM5
    • KIF 2C
    • kif2c
    • KIF2C_HUMAN
    • Kinesein Family Member 2C
    • Kinesin family member 2C
    • Kinesin like 6
    • kinesin like 6 (mitotic centromere associated kinesin)
    • Kinesin like protein 6
    • Kinesin like protein KIF2C
    • Kinesin-like protein 6
    • Kinesin-like protein KIF2C
    • KNS L6
    • KNSL 6
    • KNSL6
    • MCAK
    • MGC11883
    • Mitotic centromere associated kinesin
    • Mitotic centromere-associated kinesin
    • OTTHUMP00000010066
    • X83316
    see all
  • 機能
    Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
  • 組織特異性
    Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
  • 配列類似性
    Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
    Contains 1 kinesin-motor domain.
  • 発生段階
    Isoform 2 is expressed in fetal testis.
  • ドメイン
    The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by STK12, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Nucleus. Chromosome > centromere. Chromosome > centromere > kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Centromeric localization requires the presence of BUB1 and SGOL2.
  • Information by UniProt

参考文献

ab23137 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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