製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human

関連製品

特性

Our Abpromise guarantee covers the use of ab99367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度
    70 - 90% by HPLC.

  • 製品の状態
    Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • ATG8E
    • Autophagy-related protein LC3 A
    • Autophagy-related ubiquitin-like modifier LC3 A
    • LC3
    • LC3A
    • MAP1 light chain 3 like protein 1
    • MAP1 light chain 3-like protein 1
    • MAP1A/1B light chain 3 A
    • MAP1A/MAP1B LC3 A
    • MAP1A/MAP1B light chain 3 A
    • MAP1ALC3
    • MAP1BLC3
    • Map1lc3a
    • Microtubule associated proteins 1A/1B light chain 3
    • Microtubule-associated protein 1 light chain 3 alpha
    • Microtubule-associated proteins 1A and 1B, light chain 3
    • Microtubule-associated proteins 1A/1B light chain 3A
    • MLP3A_HUMAN
    see all
  • 機能
    Probably involved in formation of autophagosomal vacuoles (autophagosomes).
  • 組織特異性
    Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
  • 配列類似性
    Belongs to the MAP1 LC3 family.
  • 翻訳後修飾
    The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Endomembrane system. Cytoplasmic vesicle > autophagosome membrane. LC3-II binds to the autophagic membranes.
  • Information by UniProt

参考文献

ab99367 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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