製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      VLPTCPMAEFALPR
    • 領域
      28 to 41

関連製品

特性

Our Abpromise guarantee covers the use of ab23302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-MAML1 antibody (ab17019)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Mam-1
    • Mam1
    • MAML 1
    • Maml1
    • MAML1_HUMAN
    • Mastermind like 1
    • Mastermind-like protein 1
    see all
  • 機能
    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
  • 組織特異性
    Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
  • 配列類似性
    Belongs to the mastermind family.
  • ドメイン
    The C-terminal region is required for transcriptional activation.
  • 細胞内局在
    Nucleus speckle. Nuclear, in a punctate manner.
  • Information by UniProt

参考文献

ab23302 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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