製品の概要

  • 製品名
    Human Mad2L2 peptide

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      TLTRQDLNFGQV (amino acids 1-14) of human Mad2L2.
    • 領域
      3 to 14

特性

Our Abpromise guarantee covers the use of ab11254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    This product can be used as the blocking peptide for ab3630.
  • 製品の状態
    Liquid
  • 備考
    This product can be used as the blocking peptide for ab3630.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS

関連情報

  • 別名
    • Homolog of REV7 S cerevisiae
    • hREV7
    • MAD2 (mitotic arrest deficient yeast, homolog) like 2
    • MAD2 homolog
    • MAD2 like 2
    • MAD2 mitotic arrest deficient like 2
    • MAD2-like protein 2
    • MAD2B
    • Mad2l2
    • MD2L2_HUMAN
    • Mitotic Arrest Deficient 2 L2
    • Mitotic arrest deficient 2-like protein 2
    • Mitotic arrest deficient homolog like 2
    • Mitotic arrest deficient like 2 (yeast)
    • Mitotic arrest deficient yeast homolog
    • Mitotic spindle assembly checkpoint protein MAD2B
    • Polymerase (DNA directed) zeta 2 accessory subunit
    • POLZ2
    • REV 7
    • REV7
    • REV7 homolog
    • Weakly similar to Mitotic MAD2 protein (S cerevisiae)
    see all
  • 機能
    Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
  • 組織特異性
    Ubiquitously expressed.
  • 配列類似性
    Contains 1 HORMA domain.
  • 細胞内局在
    Nucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
  • Information by UniProt

参考文献

ab11254 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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