製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • アクセッション番号Q15788
    • 生物種Human
    • 配列SSDPANPDSHKRKGSPC
    • 領域8 to 24

特性

Our Abpromise guarantee covers the use of ab5848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and SRC1, catalog ab2859. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • bHLHe74
    • Class E basic helix-loop-helix protein 74
    • F SRC 1
    • Hin 2 protein
    • Hin2 protein
    • MGC129719
    • MGC129720
    • mNRC 1
    • NCoA 1
    • NCoA-1
    • Ncoa1
    • NCOA1_HUMAN
    • Nuclear receptor coactivator 1
    • Nuclear receptor coactivator protein 1
    • NY REN 52 antigen
    • Protein Hin 2
    • Protein Hin-2
    • Protein Hin2
    • Renal carcinoma antigen NY REN 52
    • Renal carcinoma antigen NY-REN-52
    • RIP 160
    • RIP160
    • SRC 1
    • SRC-1
    • Steroid receptor coactivator 1
    see all
  • 機能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
  • 組織特異性Widely expressed.
  • 関連疾患Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
  • 配列類似性Belongs to the SRC/p160 nuclear receptor coactivator family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • ドメインThe C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
    Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
  • 翻訳後修飾Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
    Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human KAT13A / SRC1 peptide (ab5848) 使用論文

ab5848 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab5848.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"