製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-QRSFFRENQQITV
    • 領域
      414 to 426

関連製品

特性

Our Abpromise guarantee covers the use of ab22947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-IRF8 antibody (ab3428)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • H ICSBP
    • H-ICSBP
    • HGNC:5358
    • HICSBP
    • ICSBP
    • ICSBP 1
    • ICSBP1
    • Interferon consensus sequence binding protein
    • Interferon consensus sequence binding protein 1
    • Interferon consensus sequence-binding protein
    • Interferon regulatory factor 8
    • IRF 8
    • IRF-8
    • Irf8
    • IRF8_HUMAN
    • MYLS
    see all
  • 機能
    Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
  • 組織特異性
    Predominantly in lymphoid tissues.
  • 配列類似性
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻訳後修飾
    Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab22947 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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