製品の概要

  • 製品名
    Anti-Human IgM antibody [MH15-1]
    Human IgM 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MH15-1] to Human IgM
  • 特異性
    The monoclonal is highly specific for the IgM isotype.
  • アプリケーション
    適用あり: IHC-P, IHC-Fr, ICCmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Isolated IgM (Human).

  • ポジティブ・コントロール
    • Tonsil.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファー
    Preservative: 0.1% Sodium Azide
    Constituents: Tris/HCl, BSA
  • Concentration information loading...
  • 精製度
    IgG fraction
  • 特記事項(精製)
    Purification by Ion Exchange Chromatography.
  • ポリ/モノ
    モノクローナル
  • クローン名
    MH15-1
  • アイソタイプ
    IgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab34029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
IHC-Fr
ICC
  • 追加情報
    ICC: 1/5 - 1/10.
    IHC-Fr: 1/5 - 1/10.
    IHC-P: 1/5 - 1/10 (based on the Indirect Method). With a normal ABC Method the dilution can be 5-10 times higher, but the optimal dilution should be tested by serial dilution. Perform protease digestion trypsin pretreatment. Dilute immediately before use with PBS or TRIS.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性
      IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.
    • 細胞内局在
      Cell Membrane and Secreted
    • 参照データベース
    • 別名
      • Immunoglobin heavy chain constant region mu edit item name - Immunoglobin heavy chain mu constant region antibody
      • Immunoglobin heavy chain constant region mu antibody
      • AGM1 antibody
      • Constant region of heavy chain of IgM antibody
      • DKFZp686I15196 antibody
      • DKFZp686I15212 antibody
      • FLJ00385 antibody
      • Ig mu chain C region antibody
      • IGHM antibody
      • IgM heavy chain constant region antibody
      • Immunoglobin heavy constant mu antibody
      • Immunoglobulin mu antibody
      • MGC104996 antibody
      • MGC52291 antibody
      • MU antibody
      • VH antibody
      see all

    参考文献

    ab34029 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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