製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab39838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HtrA2 / Omi antibody (ab36854)

    Western blot

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • High temperature requirement protein A2
    • HTRA 2
    • HtrA like serine protease
    • HtrA serine peptidase 2
    • HtrA, E. coli, homolog of, 2
    • HtrA2
    • HTRA2_HUMAN
    • mitochondrial
    • Omi stress regulated endoprotease
    • Omi stress-regulated endoprotease
    • PARK 13
    • PARK13
    • Protease serine 25
    • PRSS 25
    • PRSS25
    • Serine protease 25
    • Serine protease HTRA2
    • Serine protease HTRA2 mitochondrial
    • Serine protease htra2 mitochondrial precursor
    • Serine protease omi
    • Serine proteinase OMI
    see all
  • 機能Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
  • 組織特異性Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
  • 関連疾患Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
  • 配列類似性Belongs to the peptidase S1B family.
    Contains 1 PDZ (DHR) domain.
  • ドメインThe mature N-terminus is involved in the interaction with XIAP.
    The PDZ domain mediates interaction with MXI2.
  • 翻訳後修飾Autoproteolytically activated.
  • 細胞内局在Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
  • Information by UniProt

Human HtrA2 / Omi peptide (ab39838) 使用論文

ab39838 has not yet been referenced specifically in any publications.

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