製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • アクセッション番号5654
    • 生物種Human
    • 領域116 to 147

関連製品

特性

Our Abpromise guarantee covers the use of ab112516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-htrA1 antibody (ab38611)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% dH2O

関連情報

  • 別名
    • ARMD7
    • CARASIL
    • High-temperature requirement A serine peptidase 1
    • HtrA
    • HtrA serine peptidase 1
    • HTRA1
    • HTRA1_HUMAN
    • IGFBP5 protease
    • L56
    • ORF480
    • protease serine 11
    • Protease serine 11 (IGF binding)
    • PRSS11
    • Serine protease 11
    • Serine protease HTRA1
    • Serine protease HTRA1 precursor
    see all
  • 機能Protease that regulate the availability of nsulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Represses signaling by TGF-beta family members.
  • 組織特異性Expressed in a variety of tissues, with strongest expression in placenta.
  • 関連疾患Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.
    Defects in HTRA1 are the cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) [MIM:600142]. CARASIL is characterized by nonhypertensive cerebral small-vessel arteriopathy with subcortical infarcts, alopecia, and spondylosis, with an onset in early adulthood. On neuropathological examination, arteriosclerosis associated with intimal thickening and dense collagen fibers, loss of vascular smooth-muscle cells, and hyaline degeneration of the tunica media has been observed in cerebral small arteries.
  • 配列類似性Belongs to the peptidase S1B family.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 Kazal-like domain.
    Contains 1 PDZ (DHR) domain.
  • 細胞内局在Secreted.
  • Information by UniProt

Human htrA1 peptide (ab112516) 使用論文

ab112516 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112516.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"