Human HP1 gamma (phospho S93) peptide (ab45386)

製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab45386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HP1 gamma (phospho S93) antibody (ab45270)

  • 製品の状態
    Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • CBX 3
    • CBX3
    • CBX3_HUMAN
    • Chromobox homolog 3
    • Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
    • Chromobox protein homolog 3
    • GAMMA
    • HECH
    • Heterochromatin like protein 1
    • Heterochromatin protein 1 homolog gamma
    • Heterochromatin protein HP1 gamma
    • HP1 gamma
    • HP1 gamma homolog
    • HP1Hs gamma
    • Modifier 2 protein
    see all
  • 機能
    Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 配列類似性
    Contains 2 chromo domains.
  • 翻訳後修飾
    Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • 細胞内局在
    Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
  • Information by UniProt

参考文献

ab45386 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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