製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-NRNYWEKKQEEARK
    • 領域331 to 344

関連製品

特性

Our Abpromise guarantee covers the use of ab48060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HGS antibody (ab48014)

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

  • 再構成Please reconstitute this product in 100ul sterile water.

関連情報

  • 別名
    • Hepatocyte growth factor regulated tyrosine kinase substrate
    • Hepatocyte growth factor-regulated tyrosine kinase substrate
    • HGF-regulated tyrosine kinase substrate
    • HGNC:4897
    • HGS
    • HGS_HUMAN
    • Hrs
    • Human growth factor regulated tyrosine kinase substrate
    • Protein pp110
    • ZFYVE8
    see all
  • 機能Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
  • 組織特異性Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
  • 配列類似性Contains 1 FYVE-type zinc finger.
    Contains 1 UIM (ubiquitin-interacting motif) repeat.
    Contains 1 VHS domain.
  • ドメインHas a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
    The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
  • 翻訳後修飾Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
    Ubiquitinated by ITCH.
  • 細胞内局在Cytoplasm. Early endosome membrane. Endosome > multivesicular body membrane.
  • Information by UniProt

Human HGS peptide (ab48060) 使用論文

ab48060 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab48060.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"