製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-EDPQSKEPAGEA
    • 領域
      2 to 13

特性

Our Abpromise guarantee covers the use of ab50554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • 3' 5' exonuclease ERI 1
    • 3' 5' exonuclease ERI1
    • 3' EXO
    • 3' exoribonuclease
    • 3' HEXO
    • 3' histone mRNA exonuclease 1
    • 3''-5'' exonuclease eri1
    • 3''-5'' exoribonuclease 1
    • 3'EXO
    • 3'HEXO
    • ERI 1
    • Eri 1 homolog
    • Eri-1 homolog
    • eri1
    • Eri1 homolog
    • ERI1_HUMAN
    • HEXO
    • Histone mRNA 3' end specific exonuclease
    • Histone mRNA 3' end specific exoribonuclease
    • Histone mRNA 3''-end-specific exoribonuclease
    • Histone mRNA 3''-exonuclease 1
    • MGC35395
    • Protein 3''hExo
    • THEX 1
    • THEX1
    • Three prime histone mRNA exonuclease 1
    see all
  • 機能
    RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
  • 配列類似性
    Contains 1 exonuclease domain.
    Contains 1 SAP domain.
  • ドメイン
    The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity.
  • 細胞内局在
    Cytoplasm. Nucleus. Nucleus > nucleolus.
  • Information by UniProt

参考文献

ab50554 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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