製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-YEKKATLIKSSEE
    • 領域630 to 642

関連製品

特性

Our Abpromise guarantee covers the use of ab22944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HEC1 antibody (ab3393)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • from Entrez Gene ;
    • HEC
    • Highly expressed in cancer
    • Highly expressed in cancer protein
    • Highly expressed in cancer rich in leucine heptad repeats
    • HsHec1
    • hsNDC80
    • Kinetochore associated 2
    • Kinetochore associated protein 2
    • Kinetochore protein Hec1
    • Kinetochore protein NDC80 homolog
    • Kinetochore-associated protein 2
    • KNTC2
    • ndc80
    • NDC80 homolog kinetochore complex component
    • NDC80 kinetochore complex component homolog
    • NDC80, S. cerevisiae, homolog of
    • NDC80_HUMAN
    • Retinoblastoma associated protein HEC
    • Retinoblastoma-associated protein HEC
    • TID3
    see all
  • 機能Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
  • 配列類似性Belongs to the NDC80/HEC1 family.
  • 発生段階Expression peaks in mitosis.
  • 翻訳後修飾Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
  • 細胞内局在Nucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
  • Information by UniProt

Human HEC1 peptide (ab22944) 使用論文

ab22944 has not yet been referenced specifically in any publications.

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