Human Glucocorticoid Receptor alpha peptide (ab39764)
Key features and details
- Purity: > 90% SDS-PAGE
- Suitable for: Neutralising, Blocking
製品の詳細
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製品名
Human Glucocorticoid Receptor alpha peptide -
精製度
> 90 % SDS-PAGE. -
Animal free
No -
由来
Synthetic -
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生物種
Human -
配列
CEIITNQIPKYSNGNIKK -
領域
755 to 771
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関連製品
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Corresponding Antibody
特性
Our Abpromise guarantee covers the use of ab39764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Neutralising
Blocking - Blocking peptide for Anti-Glucocorticoid Receptor alpha antibody (ab3580)
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
Double distilled water.
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再構成Reconstitute with 0.1ml distilled water for a 0.5mg/ml solution.
関連情報
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別名
- GCCR
- GCR
- Glucocorticoid receptor
see all -
関連性
Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state. -
細胞内局在
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand; nuclear after ligand-binding.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab39764 は論文での使用が確認できていません。