製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      TNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEP

関連製品

特性

Our Abpromise guarantee covers the use of ab111659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Gli1 antibody (ab49314)

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • 再構成
    Add 100ul of distilled water. Final peptide concentration is 1 mg/ml in water.

関連情報

  • 別名
    • GLI
    • Gli 1
    • GLI family zinc finger 1
    • GLI Kruppel family member 1
    • gli1
    • GLI1_HUMAN
    • Glioma associated oncogene 1
    • Glioma associated oncogene homolog
    • Glioma associated oncogene homolog 1 (zinc finger protein)
    • Glioma-associated oncogene
    • Oncogene GLI
    • Zfp 5
    • Zfp5
    • Zinc finger protein GLI 1
    • Zinc finger protein GLI1
    see all
  • 機能
    Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
  • 組織特異性
    Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract.
  • 配列類似性
    Belongs to the GLI C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • 翻訳後修飾
    Phosphorylated in vitro by ULK3.
  • 細胞内局在
    Cytoplasm. Nucleus. Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
  • Information by UniProt

参考文献

ab111659 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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