製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gl n-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro- Ala-Lys-Leu-Gln-Pro-Arg-OH
    • 分子量
      3 kDa
    • 領域
      24 to 51
    • 配列の追加情報
      molecular formula of C149H249N47O42. Ghrelin Human contains 28 amino acids and a total molecular mass of 3370.9 Dalton and a molecular formula of C149H249N47O42.

特性

Our Abpromise guarantee covers the use of ab73131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    This peptide was purified by proprietary chromatographic techniques. Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
  • 製品の状態
    Lyophilised
  • 備考

    Total molecular mass of the peptide is 3370.9 daltons
    Molecular formula: C149H249N47OO42

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    No additives

  • 再構成
    Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

関連情報

  • 別名
    • Appetite regulating hormone
    • Ghrelin
    • Ghrelin 27
    • Ghrelin 28
    • Ghrelin and obestatin prepropeptide
    • Ghrelin/obestatin prepropeptide
    • ghrl
    • GHRL_HUMAN
    • Growth hormone releasing peptide
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • M46 protein
    • Motilin related peptide
    • Motilin-related peptide
    • MTLRP
    • Obestatin
    • Protein M46
    see all
  • 機能
    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • 組織特異性
    Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • 配列類似性
    Belongs to the motilin family.
  • 翻訳後修飾
    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • 細胞内局在
    Secreted.
  • Information by UniProt

Human Ghrelin peptide (ab73131) 使用論文

This product has been referenced in:
  • Stoyanova II & le Feber J Ghrelin accelerates synapse formation and activity development in cultured cortical networks. BMC Neurosci 15:49 (2014). Read more (PubMed: 24742241) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab73131.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録