Human GAD67 ChIP Primer and Probe Set (ab85780)

製品の概要

  • 製品名Human GAD67 ChIP Primer and Probe Set
  • 製品の概要

    Accession number: NM_000817.
    The HsGAD67 primers and probe can be used to quantify a control locus in chromatin immunoprecipitation (ChIP) assays with chromatin prepared from human cells.

    GAD1 (Glutamic acid decarboxylase) is expressed in neurons but silenced in most other cell types. The primers and probe are located in exon 1, within 1 kb of the transcription start site. In most cell types GAD1 is enriched with histone modifications associated with silencing (e.g. Histone H3 K9 mono methylation, see image with ab9045). Whereas it shows low levels of histone modifications associated with active gene transcription such as Histone H3 K9 acetylation (see image with ab4441).

製品の特性

  • 機能Catalyzes the production of GABA.
  • 組織特異性Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain.
  • 関連疾患Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:603513]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.
  • 配列類似性Belongs to the group II decarboxylase family.
  • Information by UniProt
  • 別名
    • 67 kDa glutamic acid decarboxylase
    • CPSQ1
    • DCE1
    • DCE1_HUMAN
    • EC 4.1.1.15
    • FLJ45882
    • GAD
    • GAD 67
    • GAD-67
    • GAD1
    • Glutamate decarboxylase 1
    • Glutamate decarboxylase 1 (brain, 67kDa)
    • Glutamate decarboxylase 1 brain 67kD
    • Glutamate decarboxylase 1 brain 67kDa
    • Glutamate decarboxylase 67 kDa isoform
    • Glutamate decarboxylase, brain, 67-KD
    • OTTHUMP00000041055
    • SCP
    see all

Human GAD67 ChIP Primer and Probe Set (ab85780) 使用論文

ab85780 has not yet been referenced specifically in any publications.

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We have tested some of our RNA polymerase II antibodies against both inactive genes and the 3' end of active genes. Below is a link to the antibodies.

http://www.abcam.com/RNA-polymerase-II-CTD-repeat-...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"