Human G protein beta subunit like peptide (ab39766)

製品の概要

  • 製品名Human G protein beta subunit like peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab39766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • G protein beta subunit like
    • G protein beta subunit-like
    • Gable
    • GbetaL
    • GBL
    • GBL protein
    • LST8
    • LST8_HUMAN
    • Mammalian lethal with SEC13 protein 8
    • MGC111011
    • mLST8
    • MTOR associated protein LST8 homolog (S. cerevisiae)
    • POP3
    • POP3 homolog (S. pombe)
    • Protein GbetaL
    • Target of rapamycin complex subunit LST8
    • TORC subunit LST8
    • WAT1
    • WAT1 homolog (S. pombe)
    see all
  • 機能Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
  • 組織特異性Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
  • 配列類似性Belongs to the WD repeat LST8 family.
    Contains 7 WD repeats.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Human G protein beta subunit like peptide (ab39766) 使用論文

ab39766 has not yet been referenced specifically in any publications.

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