製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-GVYSRPIMNSS
    • 領域447 to 457

関連製品

特性

Our Abpromise guarantee covers the use of ab23065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-FOXA2 antibody (ab5074)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • Forkhead box A2
    • Forkhead box protein A2
    • FOX A2
    • foxa2
    • FOXA2_HUMAN
    • Hepatic nuclear factor 3 beta
    • Hepatocyte nuclear factor 3
    • Hepatocyte nuclear factor 3 beta
    • Hepatocyte nuclear factor 3-beta
    • HNF 3B
    • HNF-3-beta
    • HNF-3B
    • HNF3B
    • MGC19807
    • TCF 3B
    • TCF-3B
    • TCF3B
    • Transcription factor 3B
    see all
  • 機能Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
  • 配列類似性Contains 1 fork-head DNA-binding domain.
  • 翻訳後修飾Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
  • 細胞内局在Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner and in response to insulin signaling via AKT1 is exported from the nucleus.
  • Information by UniProt

Human FOXA2 peptide (ab23065) 使用論文

ab23065 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23065.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"