製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列EVPAAGRVPA-C
    • 領域2 to 11

特性

Our Abpromise guarantee covers the use of ab23088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • CCFDN
    • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
    • CTD of POLR2A, phosphatase of, subunit 1
    • CTDP1
    • CTDP1_HUMAN
    • EC 3.1.3.16
    • RNA polymerase II subunit A C terminal domain phosphatase
    • RNA polymerase II subunit A C-terminal domain phosphatase
    • Serine phosphatase FCP1a
    • TFIIF associating CTD phosphatase
    • TFIIF-associating CTD phosphatase
    • TFIIF-associating CTD phosphatase 1
    • Transcription factor IIF-associating CTD phosphatase 1
    see all
  • 機能Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II.
  • 組織特異性Ubiquitously expressed. Isoform 3 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and placenta.
  • 関連疾患Defects in CTDP1 are a cause of congenital cataracts facial dysmorphism and neuropathy syndrome (CCFDN) [MIM:604168]. CCFDN is an autosomal recessive developmental disorder that occurs in an endogamous group of Vlax Roma (Gypsies). The syndrome is characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures).
  • 配列類似性Contains 1 BRCT domain.
    Contains 1 FCP1 homology domain.
  • 翻訳後修飾Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human FCP1 peptide (ab23088) 使用論文

ab23088 has not yet been referenced specifically in any publications.

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