製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-EAAQSPYRAVVQIF
    • 領域280 to 293

特性

Our Abpromise guarantee covers the use of ab23100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • F box protein that recognizes sugar chains 2
    • F box G domain protein 2
    • F box only protein 6
    • F box protein 6
    • F box protein FBG2
    • F box protein Fbx6
    • F box/G domain protein 2
    • F-box only protein 6
    • F-box protein that recognizes sugar chains 2
    • F-box/G-domain protein 2
    • FBG 2
    • FBG2
    • FBS 2
    • FBS2
    • FBX 6
    • FBX6
    • FBX6_HUMAN
    • FBXO 6
    • FBXO6
    • OTTHUMP00000002267
    see all
  • 機能Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 F-box domain.
    Contains 1 FBA (F-box associated) domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Human FbxO6 peptide (ab23100) 使用論文

ab23100 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"