Human Estrogen Receptor beta peptide (ab41764)

製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列CSPAEDSKSKEGSQNPQSQ
    • 領域467 to 485

関連製品

特性

Our Abpromise guarantee covers the use of ab41764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ERb, ab5786.
  • アプリケーション

    Neutralising

    Blocking - Blocking peptide for Anti-Estrogen Receptor beta antibody (ab5786)

  • 精製度> 95 % SDS-PAGE.
    >95% pure.
  • 製品の状態Liquid
  • 備考This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ERb, ab5786.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • ER BETA
    • ER-beta
    • Erb
    • ESR B
    • ESR BETA
    • ESR2
    • ESR2_HUMAN
    • ESRB
    • ESTRB
    • estrogen nuclear receptor beta variant a
    • estrogen nuclear receptor beta variant b
    • Estrogen receptor 2
    • estrogen receptor 2 (ER beta)
    • Estrogen receptor beta
    • estrogen receptor beta 4
    • NR3A2
    • Nuclear receptor subfamily 3 group A member 2
    see all
  • 機能Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
  • 組織特異性Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human Estrogen Receptor beta peptide (ab41764) 使用論文

ab41764 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab41764.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"