製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-SGWKEEEVLQSRN
    • 領域359 to 371

関連製品

特性

Our Abpromise guarantee covers the use of ab22940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-ESE1 antibody (ab2934)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • E74 like factor 3
    • E74 like factor 3 ets domain transcription factor
    • E74 like factor 3 ets domain transcription factor epithelial specific
    • E74 like factor 3 ETS domain transcription factor serine box epithelial specific
    • E74-like factor 3
    • Elf3
    • ELF3_HUMAN
    • Epithelial restricted with serine box
    • Epithelial-restricted with serine box
    • Epithelium restricted Ets protein ESX
    • Epithelium specific Ets factor 1
    • Epithelium specific Ets transcription factor 1
    • Epithelium-restricted Ets protein ESX
    • Epithelium-specific Ets transcription factor 1
    • EPR 1
    • EPR1
    • ERT
    • ESE-1
    • ESX
    • Ets domain transcription factor serine box
    • Ets domain transcription factor serine box epithelial specific
    • Ets transcription factor
    • ETS-related transcription factor Elf-3
    • jen
    • MGC139318
    see all
  • 機能Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
  • 組織特異性Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
  • 配列類似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • ドメインthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • 細胞内局在Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
  • Information by UniProt

Human ESE1 peptide (ab22940) 使用論文

ab22940 has not yet been referenced specifically in any publications.

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