製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列YGSARSVGKVEPS-C (N-Terminus)

関連製品

特性

Our Abpromise guarantee covers the use of ab45484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-ERC1 antibody (ab21192)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • Cast 2
    • CAST2
    • CAZ associated structural protein 2
    • Elks
    • ELKS/RAB6 interacting/CAST family member 1
    • ELKS/RAB6-interacting/CAST family member 1
    • ERC 1
    • ERC protein 1
    • ERC-1
    • Erc1
    • ERC1 protein
    • KIAA1081
    • MGC12974
    • RAB6 interacting protein 2
    • RAB6-interacting protein 2
    • RAB6IP2
    • RB6I2_HUMAN
    see all
  • 機能Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • 組織特異性Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • 関連疾患Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • 配列類似性Contains 1 FIP-RBD domain.
  • 細胞内局在Cytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt

Human ERC1 peptide (ab45484) 使用論文

ab45484 has not yet been referenced specifically in any publications.

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