The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-ELMO1 antibody (ab2239)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Ced 12 homolog
Ced 12 homolog 1
Ced12 homolog 1
Engulfment and cell motility 1
Engulfment and cell motility protein 1
Protein ced-12 homolog
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Widely expressed, with a higher expression in the spleen and placenta.
Contains 1 ELMO domain. Contains 1 PH domain.
Phosphorylated by HCK.
Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.