製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-LAIKTKNFGFV
    • 領域2789 to 2799

関連製品

特性

Our Abpromise guarantee covers the use of ab23029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-EDD antibody (ab4376)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • 4432411E13Rik
    • AW549941
    • C77315
    • D030042K14
    • DD5
    • E3 identified by differential display
    • E3 ubiquitin protein ligase, HECT domain containing, 1
    • E3 ubiquitin-protein ligase
    • E3 ubiquitin-protein ligase UBR5
    • EDD
    • EDD 1
    • EDD1
    • FLJ11310
    • HECT domain-containing 1
    • hHYD
    • HYD
    • Hyperplastic discs protein homolog
    • Hyperplastic discs, Drosophila, homolog of
    • KIAA0896
    • MGC57263
    • mKIAA0896
    • Progestin induced protein
    • Progestin-induced protein
    • Rat100
    • Ubiquitin protein ligase
    • Ubiquitin protein ligase E3 component n recognin 5
    • UBR5
    • UBR5_HUMAN
    see all
  • 機能E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
  • 組織特異性Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 1 PABC domain.
    Contains 1 UBR-type zinc finger.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human EDD peptide (ab23029) 使用論文

ab23029 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"