製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-LHRTETFPAYRSEH
    • 領域293 to 306

関連製品

特性

Our Abpromise guarantee covers the use of ab45623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-DOK5 antibody (ab24360)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • chromosome 20 open reading frame 180
    • Docking protein 5
    • DOK 5
    • DOK5
    • DOK5 protein
    • DOK5_HUMAN
    • Downstream of tyrosine kinase 5
    • Insulin receptor substrate 6
    • IRS-6
    • IRS6
    see all
  • 機能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 組織特異性Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 配列類似性Belongs to the DOK family. Type B subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • ドメインPTB domain mediates receptor interaction.
  • 翻訳後修飾Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Information by UniProt

Human DOK5 peptide (ab45623) 使用論文

ab45623 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"