製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab21999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Dnmt1 antibody (ab19905)

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • ADCADN
    • AIM
    • CXXC finger protein 9
    • CXXC-type zinc finger protein 9
    • CXXC9
    • DNA (cytosine 5 ) methyltransferase 1
    • DNA (cytosine-5)-methyltransferase 1
    • DNA methyltransferase 1
    • DNA methyltransferase HsaI
    • DNA methyltransferase M.HsaI.
    • DNA MTase
    • DNA MTase HsaI
    • DNMT
    • DNMT 1
    • Dnmt1
    • DNMT1_HUMAN
    • Dnmt1o
    • FLJ16293
    • HSN1E
    • M.HsaI
    • MCMT
    • Met1
    • MGC104992
    • mMmul
    • MommeD2
    see all
  • 機能Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
  • 組織特異性Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
  • 配列類似性Belongs to the C5-methyltransferase family.
    Contains 2 BAH domains.
    Contains 1 CXXC-type zinc finger.
  • ドメインThe N-terminal part is required for homodimerization and acts as a regulatory domain.
  • 翻訳後修飾Sumoylated; sumoylation increases activity.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human Dnmt1 peptide (ab21999) 使用論文

This product has been referenced in:
  • Desplats P  et al. Alpha-synuclein sequesters DNMT1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem : (2011). Blocking . Read more (PubMed: 21296890) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"