製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      ATYSSKARLHVCQKI
    • 領域
      245 to 259

関連製品

特性

Our Abpromise guarantee covers the use of ab45461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-DKK2 antibody (ab21187)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • Dickkopf 2
    • Dickkopf gene 2
    • Dickkopf homolog 2
    • Dickkopf related protein 2
    • Dickkopf WNT signaling pathway inhibitor 2
    • Dickkopf-2
    • Dickkopf-related protein 2
    • Dickkopf2
    • DKK 2
    • Dkk-2
    • Dkk2
    • DKK2_HUMAN
    • hDkk 2
    • hDkk-2
    • hDkk2
    see all
  • 機能
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 組織特異性
    Expressed in heart, brain, skeletal muscle and lung.
  • 配列類似性
    Belongs to the dickkopf family.
  • ドメイン
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻訳後修飾
    May be proteolytically processed by a furin-like protease.
  • 細胞内局在
    Secreted.
  • Information by UniProt

Human DKK2 peptide (ab45461) 使用論文

ab45461 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45461.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録