製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      ATYSSKARLHVCQKI
    • 領域
      245 to 259

関連製品

特性

Our Abpromise guarantee covers the use of ab45461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-DKK2 antibody (ab21187)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • Dickkopf 2
    • Dickkopf gene 2
    • Dickkopf homolog 2
    • Dickkopf related protein 2
    • Dickkopf WNT signaling pathway inhibitor 2
    • Dickkopf-2
    • Dickkopf-related protein 2
    • Dickkopf2
    • DKK 2
    • Dkk-2
    • Dkk2
    • DKK2_HUMAN
    • hDkk 2
    • hDkk-2
    • hDkk2
    see all
  • 機能
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 組織特異性
    Expressed in heart, brain, skeletal muscle and lung.
  • 配列類似性
    Belongs to the dickkopf family.
  • ドメイン
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻訳後修飾
    May be proteolytically processed by a furin-like protease.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab45461 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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