製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab39755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    Blocking - Blocking peptide for Anti-DEDD2 antibody (ab36858)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • Death effector domain containing 2
    • Death effector domain-containing DNA-binding protein
    • Death effector domain-containing protein
    • Death effector domain-containing testicular protein
    • DED containing protein FLAME 3
    • DEFT
    • DNA binding death effector domain containing protein 2
    • DNA-binding death effector domain-containing protein 2
    • FADD like anti apoptotic molecule 3
    • FLAME 3
    see all
  • 関連性Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
  • 細胞内局在Nuclear, accumulated in subnuclear structures resembling nucleoli.

Human DEDD2 peptide (ab39755) 使用論文

ab39755 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"