製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列の追加情報21 amino acids near the carboxy terminus of human DC-SIGN

関連製品

特性

Our Abpromise guarantee covers the use of ab6091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-DC-SIGN antibody (ab5715)

  • 製品の状態Liquid
  • 備考

    The peptide is used for blocking the antibody activity of anti-CD209 (ab5715). It usually blocks the antibody activity completely in Western blot by incubating the peptide with an equal volume of antibody for 30 min at 37°C.

    Stable for one year.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • C type lectin domain family 4 member L
    • C-type lectin domain family 4 member L
    • CD 209
    • CD209
    • CD209 antigen
    • CD209 antigen-like protein A
    • CD209 molecule
    • CD209_HUMAN
    • Cd209a
    • CDSIGN
    • CIRE
    • CLEC4L
    • DC SIGN
    • DC SIGN1
    • DC-SIGN
    • DC-SIGN1
    • DCSIGN
    • Dendritic cell specific ICAM 3 grabbing nonintegrin 1
    • Dendritic cell specific ICAM3 grabbing nonintegrin 1
    • Dendritic cell-specific ICAM-3-grabbing non-integrin 1
    • Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
    • Dengue fever, protection against, included
    • Dentritic Cell Specific ICAM3 Grabbing Nonintegrin
    • HIV GP120 Binding Protein
    • MGC129965
    • MGC130443
    • SIGN-R1
    • SIGNR5
    see all
  • 機能Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
    On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
  • 組織特異性Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
  • 配列類似性Contains 1 C-type lectin domain.
  • ドメインThe tandem repeat domain, also called neck domain, mediates oligomerization.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt

Human DC-SIGN peptide (ab6091) 使用論文

ab6091 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"