Human Cytochrome P450 17A1 peptide (ab48065)

製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列LFKDGDQKLEK
    • 領域134 to 144

関連製品

特性

Our Abpromise guarantee covers the use of ab48065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • 20 lyase
    • CP17A_HUMAN
    • CPT7
    • CYP17
    • CYP17A1
    • CYPXVII
    • Cytochrome P450 17A1
    • Cytochrome P450 family 17
    • Cytochrome P450 family 17 subfamily A polypeptide 1
    • Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia
    • Cytochrome p450 XVIIA1
    • Cytochrome P450-C17
    • Cytochrome P450c17
    • OTTHUMP00000020382
    • P450 C17
    • P450c17
    • S17AH
    • Steroid 17 alpha hydroxylase/17,20 lyase
    • Steroid 17 alpha monooxygenase
    • Steroid 17-alpha-hydroxylase/17
    • Steroid 17-alpha-monooxygenase
    see all
  • 機能Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
  • パスウェイLipid metabolism; steroid biosynthesis.
  • 関連疾患Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).
  • 配列類似性Belongs to the cytochrome P450 family.
  • 翻訳後修飾Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
  • 細胞内局在Membrane.
  • Information by UniProt

Human Cytochrome P450 17A1 peptide (ab48065) 使用論文

ab48065 has not yet been referenced specifically in any publications.

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